The Human Neuroimaging and Biotransport Laboratory (HNBL) is at the forefront of integrating advanced human functional MRI techniques into clinical applications. Our interdisciplinary team consists of scientists, engineers, and clinicians from diverse fields such as neuroimaging, MR physics, cognitive neuroscience, neurosurgery, biomedical engineering, and mechanical engineering. Together, we pioneer innovative approaches to better understand human brain function.

We focus on merging cutting-edge biotransport modeling with high-resolution functional MRI (fMRI) to unravel the complexities of neurovascular and neurometabolic coupling, which underlie the blood oxygenation level dependent (BOLD) signal. Our research investigates the BOLD hemodynamic response function (HRF) and cerebrovascular reactivity (CVR) to assess microvascular health and vascular function, with implications for a range of brain pathologies such as mild traumatic brain injury, epilepsy, dementia, and Alzheimer's disease.

By developing diagnostic tools that extend beyond structural abnormalities, we aim to revolutionize clinical fMRI brain mapping and improve patient care by providing deeper insights into brain function and pathology.